Ibutamoren, more commonly known as “MK-677”, is the most powerful and potent orally administered growth hormone secretagogue, when it comes to selective androgen receptor modulators, also known as “SARMs”. Simply put, a secretagogue is a substance that chemically signals the pituitary gland to increase secretion of growth hormone
If you would like to see safe and natural growth hormone boosters, view our 5 Best HGH Boosters here.
MK-677 could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn’t require any injections, nor does it have similar side effects. Originally developed by Reverse Pharmacology, MK-677 aimed to combat conditions like muscle wasting, obesity, osteoporosis, and, oddly enough, the treatment of elderly hip fracture patients,
How MK-677 Works
MK-677 works as growth hormone pulse intensifier, which can be increase through four possible mechanisms:
- Increasing the release of GHRH, or “Growth Hormone Releasing Hormone”
- Amplifying GHRH signaling in the somatotrophs of the anterior pituitary gland
- Reducing somatostatin release, which “turns of” the release of growth hormone; and by
- Inhibiting the signaling of the somatostatin receptor
The incredible part being that MK-677 was found to successfully maneuver through all four of these mechanisms. Post-ingestion, growth hormone levels were shown to increase, relative to dosage, starting at 5 mg per day.
In a study on its effects on catabolic states, a once-daily, oral dose of 25 mg was administered to a group of healthy males who were subjected to short-term diet-induced nitrogen wasting. After 7 days at this monitored dosage, the subjects showed a sustained increase in serum concentration of IGF-1 and growth hormone. In addition, nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting.
Another study, focused on the effects of MK-677 on its ability to fight obesity showed increases in lean body mass, but didn’t affect visceral adipose tissue (fat found beneath the skin and around internal organs). This study, similarly to the first one mentioned above, issued 25 mgs per day, but for an extended period of 8 weeks. The subjects showed increases in basal metabolic rate after 2 weeks, as well as an increase in growth hormone, IGF-1, and IGF-1 binding protein-3 serum levels. The increases in lean body mass were hypothesized to be caused by increased calorie deposition into the muscle and appetite suppressions, as opposed to the reduction of fat storage directly.
A third study, conducted for the treatment of osteoporosis and bone mineral density, also showed some increases in bone density, which is further justification to believe its impact on bone mineral density. This element of MK-677, when applied to everyday athletes and bodybuilders, increases the support for injury rehabilitation and recovery while cycling.
Furthermore, additional potential health benefits associated with MK-677 supplementation are associated with increased energy levels, nitrogen retention and strength, as well as improved sleep, complexion, and overall sense of well being. Additionally, multiple studies also suggest MK-677 to increase immune system response, allowing a general boost to the body’s immune system.
MK-677 for Decreasing Fat & Increasing Lean Mass
For serious bodybuilders and athletes looking to take their training to the next level, MK-677 is one of the most effective and talked about growth hormone supplements / SARMs available, legally.
As the research indicates, MK-677 has been shown to be highly successful in a number of applications, but most notably for growing muscle mass, to help build that “shredded” physique. Because it’s non-comparable to the levels of growth hormone absorbed from an exogenously administered human growth hormone supplements, you’re able to use MK-677 as an HGH cycle without having to deal with painful, unsanitary, and tedious daily injections. Simply put, it provides similar benefits of HGH injections, without the use for needles and injections.
In terms of what to expect, a multitude of MK-677 studies showed increased IGF-1 levels by roughly 40-90%, which results in a host of additional benefits, such as:
- Increased Fat Oxidation (Fat Loss)
- Increased Muscle Gains (Lean Mass)
- Tightening of Loose Skin
- Injury Rehabilitation
- Increased Healing Rate in Bones, Tendons, and Ligaments
It’s common to see increases of 6 pounds of lean muscle mass within an 8-week cycle. These are pretty substantial gains even by way of HGH injections, but now… there’s a legal, orally administered, and effective alternative.
The most common doses of MK-677 range between 5-25mgs per day. In some cases, we’ve seen doses upwards of 50mgs per day, but these are few and far between, and didn’t result in exponential benefits above the recommended top-end dosage of 20-25mgs per day.
What We’re Looking for in our Best MK-677 Supplements
When judging what to look for in a selective androgen receptor modulator, or SARM, like Ibutamoren (MK-677), it’s a different process than say, pre-workouts, fat burners, or protein powders. Containing only the single active ingredient, as opposed to a dozen or more, we’re looking at the following elements:
- Per-Serving Dosage: Of the active ingredients, ®-1’-(2-methylalanyl-O-benzyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[indole-3,4’-piperidine], which is the systematic name of Ibutamoren.
- Per Bottle Dosage: Here, we’re looking for the amount of total mgs that you get for your money.
- Price: On a per serving basis, we’re looking to analyze the value of each product.
Best MK-677 Supplements – Top 3
Through all of our research, customer reviews, and hard facts, we’ve found, what we believe to be, the best MK-677 supplements on the market. Take the time to do your own research – we’re confident you’re going to love it!
#3 – MK-677 by DNA Anabolics
DNA Anabolics has long been a leader in the world of performance enhancing supplements, but more specifically, SARMs like Ibutamoren. What we love most about their offer is the amount of research they provide to their customers, who more often than not, are new to the use of Ibutamoren. Despite DNA Anabolics’ expertise in SARM supplements, they charge an ultra premium price of $150 per 90-capsule bottle.
- Ultra Premium Price
- 90 Capsules
- SARM Specialists
#2 – MK-677 (Ibutamoren) by Progen Peptides
If you haven’t already checked our Progen peptides, we highly recommend it. Their product suite includes a full SARM and peptide lineup, which provides a great opportunity for powerful stacks. In terms of dosage, MK-677 (Ibutamoren) comes in a 25mg / 30ml serving. As the only liquid supplement on our best MK-677 supplements list, we’re excited to learn more about your personal experiences with the liquid version over the capsules.
Progen Peptides Highlights:
- Liquid Administration
- 25mg / 30ml
#1 – MK ULTRA by Blackstone Labs
Blackstone Labs is one the most well-known brands in the supplement industry, specializing in SARMs, in particular. With only 10mg per serving, Blackstone Labs offers a great alternative for bodybuilders and athletes new to the use of Ibutamoren MK-677 and who are looking to start at a lower dosage.
Blackstone Labs Highlights:
- 10mg Per Serving
- 60 Capsules
MK-677 Ibutamoren Round-Up
If you took the time to read through this entire article to educate yourself on the mechanism, benefits, and dosages of the growth hormone, MK-677 Ibutamoren, we applaud you! This stuff is quickly becoming one of the hottest supplements on the market, and for good reason. Athletes and bodybuilders around the world are having incredible results. Do yourself a favor and mix in one the best MK-677 supplements into your regimen!