The Deal on Ostarine Supplements

The Deal on Ostarine Supplements

Ostarine is the most powerful and anabolic selective androgen receptor modulator (“SARM”) available to the bodybuilding and fitness community, hands down, and without competition.

Ostarine, also known as “MK-2866” or “Enobosarm”, was originally developed by GTx, a global pharmaceutical company that focuses on the development of small molecules that selectively modify the effects of androgen and estrogen receptors. Through its extensive research, GTx has found that Ostarine:

  • Is a non-steroidal androgen receptor agonist that binds to the androgen receptors with high affinity and selectivity
  • Does not bind the estrogen receptor and thus, cannot be converted to estrogenic metabolites
  • Demonstrates a lack of masculinizing and other side effects generally associated with steroidal and non-steroidal androgen use in postmenopausal women
  • Increases lean body mass, improves performance, enhances libido, decreases bone turnover (potentially resistant to metastasis)
  • Increases quality of life
  • Stimulates testosterone’s actions in bone, muscle, and the brain; and
  • Blocks testosterone’s actions in the prostate and skin

With these clinically researched benefits (these are not exaggerated whatsoever and are associated directly with the original Ostarine clinical trial), the team at Supplement Demand set out to find the best Ostarine supplements available to our readers.

How Does Ostarine Work?

Ostarine (MK-2866) CompoundBeing classified as a selective androgen receptor modulator, Ostarine creates anabolic activity at selective androgen receptors (hence, the name), but not others. When compared to test-boosters and traditional anabolic steroids, SARMs are far more advantageous due to their lack of androgenic activity in non-skeletal muscle tissues.

In fact, Ostarine binds to the androgen receptor, which serves as a DNA-binding “transcript” that regulates the body’s gene expression and demonstrates osteo- (bone) and myo- (muscular) activity.

Ostarine’s selective process of binding and activating the androgen receptor (in doing so, altering the expression of our genes) helps to increase protein synthesis, which in turn, helps to significantly increase growth and rate of muscle development.

In layman’s terms, the best Ostarine supplements provide similar muscle growth benefits as steroids, but without the negative anabolic side effects that result in the growth of the prostate and secondary sexual organs.

By targeting muscle tissues almost exclusively, Ostarine and other similar SARMs yield significant potential for bodybuilders, power lifters, athletes, and fitness enthusiasts alike. Proactive benefits aside, Ostarine also shows reactive benefits in terms of treatments for a multitude of muscle-wasting diseases and hormone replacement therapy.

Best Ostarine Uses

With benefits ranging from increased muscle mass to fat loss to muscle-wasting prevention, it’s no surprise how diverse Ostarine is in its efficiencies for multiple different types of fitness regimens. Below, we dive a bit into its ability to yield results during a bulk, cut, and also body recomposition phase, for men and women.

Bulking with Ostarine

Primarily, Ostarine is used for bulking and gaining lean muscle due to it being the most anabolic of all the SARMs supplements.

Users typically experience increases in lean muscle in the range of 7-9 pounds during an 8-week cycle of 25-30mg per day. These muscle gains remained very stable in the sense that they didn’t deplete once the Ostarine cycle came to an end.

Generally, with Ostarine, the higher the daily dose, the more testosterone suppression. This suppression is nothing comparable to the suppression traditionally experienced with anabolic steroids, but regardless, we recommend running a “mini” post-cycle therapy (PCT) for any Ostarine cycle longer than 4 weeks.

An estrogen blocker, or SERM (selective estrogen receptor modulator), isn’t required during this PCT, either.

Cutting with Ostarine

For those with cutting (eating to a daily caloric deficit) experience, you’re most likely familiar with the all-too-common loss of lean muscle during a cut. And there’s nothing more discouraging than seeing all of your hard work diminish day after day.

As it relates to cutting, Ostarine’s protocol calls for the maintenance of muscle mass, all while reducing calories. Due to its anabolic effects, as a dieter, you’re able to prevent significant muscle and strength loss with the help of Ostarine’s “nutrient partitioning” effects.

A daily doses of 15-20 mg is recommended for a 6-8 week cycle when cutting, in order to avoid any minor side effects related to testosterone suppression.

Body Recomposition with Ostarine

Body recomposition is a process that requires not only a high degree of discipline, but also time, inevitably, as you’re ultimately trying to gain muscle, while simultaneously losing fat.

As mentioned above, Ostarine offers significant nutrient partitioning benefits, which allows you to burn calories from stored body fat, not muscle. Another benefit that shines during a body recomp is the fact that Ostarine is taken orally, most often in capsule form, and is not methylated. Being non-methylated, in Ostarine’s case, allows it to be non-toxic and an effective aid in decreasing blood pressure.

A daily dose of 20-25 mg is recommended for a 6-8 week cycle, along with a highly optimized diet with at least 30% of macronutrients coming from lean protein sources.

Ostarine Half-Life

Ostarine has a half-life of 23.8 hours, which makes it perfect as a once-a-day supplement for maximum efficiency. Depending on which of our best Ostarine supplements you choose, however, you will need to take Ostarine multiple times per day (varying serving sizes per product), in order to hit the recommended daily doses for your specific fitness goals (bulk, cut, recomp, etc.)

Ostarine and Estrogen – Do you need an Estrogen Blocker?

SARMs do not aromatize, which is the body’s process of converting anabolic steroids and testosterone into estrogen, conferring all their effects to androgen receptor (AR) binding, and not the metabolic conversion to active androgens and estrogens.

If you are concerned about slight increases in estrogen, you can always take your favorite estrogen blocker as an added precaution.

Advantages of Ostarine vs. Steroids

To reiterate, we want you to fully understand the benefits of Ostarine, specifically as they relate to the substitution with traditional anabolic steroids. With that said, Ostarine:

  • Is non-methylated (non-toxic to the liver)
  • PCT isn’t necessary (some suppression may be present for cycles longer than 4 weeks at a daily dose of 25 mg)
  • Ingested orally (no more injections)
  • Anabolic effects (even at extremely low doses of 3-5 mg per day)
  • Great for bulking, cutting, body recomposition, and injury rehabilitation

What We’re Looking for in our Best Ostarine Supplements

Ostarine supplements are incredibly different in terms of “what we’re looking for” because the compound itself is the actual “supplement”. They differ from pre-workouts, fat burners, and protein powders, which tend to have 10 to 20 different ingredients, all at varying doses, etc.

So, what we’re looking for, specifically, is very simple:

  • Per-Serving Dosage: Of the active ingredient, ((2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide), which is the systematic name for Ostarine.
  • Per-Bottle Dosage: Total mg of Ostarine per bottle.

Best Ostarine SupplementsDISCONTINUED

At this time, all Ostarine products, distribution, supplements, and sales in the US have been forcibly halted. This is because of the intense legal controversy surrounding it in regards to the FDA. As a result, we can no longer list, suggest or point you in the direction of Ostarine at this time. While unfortunate, there is nothing we can do except wait and hope for its approval.

Alternatives to Ostarine (safe and effective)

Instead of taking Ostarine, which is now illegal, you can consider natural test boosters like these we’ve ranked.


If you have any questions or concerns, make sure to leave a comment below!

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